Tissue Engineering Animal Models
The following animals have been used with the Extracel™ technology:
New Zealand white rabbits 1-9
Hartley pigmented guinea pigs 10,11
Adult Sprague-Dawley rats 12,13
Female wistar rats 14
Genetically diabetic female mice (C57BLKs/J-m1/db, db/db) 15-17
Female Yorkshire pigs 18
Female athymic nude mice 19
Male nude mice 20,21
1. C. Sondrup, Y. Liu, X.Z. Shu, G.D. Prestwich, and M.E. Smith, “Cross-linked hyaluronan-coated stents in the prevention of airway stenosis,” Otolaryngol. Head & Neck Surg., 135(1), 28-35 (2006).
2. Y. Liu, X.Z. Shu, G.P. Prestwich, “Osteochondral Defect Repair with Autologous Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable, In Situ Crosslinked Synthetic Extracellular Matrix,” Tissue Eng., 12(12), 3405-3416 (2006).
3. J.K. Hansen, S.L. Thibeault, J.F. Walsh, X.Z. Shu, and G.D. Prestwich, “In Vivo Engineering of the Vocal Fold ECM with Injectable HA Hydrogels: Early Effects on Tissue Repair and Biomechanics in a Rabbit Model,” Ann. Otol. Rhinol. Laryngol., 114, 662-670 (2005).
4. S. Duflo, S.L. Thibeault, W. Li, X.Z. Shu, and G.D. Prestwich, “Effect of a Synthetic Extracellular Matrix on Vocal Fold Lamina Propria Gene Expression in Early Wound Healing,” Tissue Eng.,12(11), (2006).
5. S. Duflo, S.L. Thibeault, W. Li, X.Z. Shu, and G.D. Prestwich, “Vocal Fold Tissue Repair In Vivo Using a Synthetic Extracellular Matrix,” Tissue Eng., 12(8), 2171-2180. (2006).
6. M. Proctor, K. Proctor, X.Z. Shu, L.D. McGill, G.D. Prestwich, and R.R. Orlandi, “Composition of Hyaluronan Affects Wound Healing in the Rabbit Maxillary Sinus,” Am. J. Rhinology, 20, 206-211 (2006).
7. R.C. Connors, J.J. Muir, Y. Liu, G.R. Reiss, P.C. Kouretas, M.G Whitten, T.K. Sorenson, G.D. Prestwich, and D.A. Bull, “Postoperative Pericardial Adhesion Prevention Using Carbylan‑SX in a Rabbit Model,” J. Surg. Res., 140, 237-242 (2007).
8. Y. Liu, A. Skardal, X.Z. Shu, and G.D. Prestwich, “Prevention of Peritendinous Adhesions Following Flexor Tendon Injury with CarbylanÔ-SX, a Semisynthetic Glycosaminoglycan Hydrogel,” J. Orthopedic Res., in press (2008).
9. R.R. Orlandi, X.Z. Shu, L. McGill, E. Petersen, and G.D. Prestwich, “Structural Variations in a Single Hyaluronan Derivative Significantly Alter Wound-Healing Effects in the Rabbit Maxillary Sinus,” Laryngoscope, 117, 1288-1295 (2007).
10. A.H. Park, C.W. Hughes, A. Jackson, L. Hunter, L. McGill, S.E. Simonsen, S.C. Alder, X.Z. Shu, and G.D. Prestwich, “Crosslinked Hydrogels for Tympanic Membrane Repair,” Otolaryngol. Head Neck Surg., 135(6), 877-883 (2006).
11. A.H. Park, A. Jackson, L. Hunter, L. McGill, S.E. Simonsen, S.C. Alder, X.Z. Shu, and G.D. Prestwich, “Crosslinked Hydrogels for Middle Ear Packing,” Otol. Neurotol., 27(8), 1170-1175 (2006).
12. Y. Liu, S. Ahmad, X.Z. Shu, R.K. Sanders, S.A. Kopesec, and G.D. Prestwich, “Accelerated Repair of Cortical Bone Defects Using a Synthetic Extracellular Matrix to Deliver Human Demineralized Bone Matrix,” J. Orthoped. Res., 24(7), 1454-1462 (2006).
13. E.M. Horn, M. Beaumont, X.Z. Shu, A. Harvey, G.D. Prestwich, K.M. Horn, A.R. Gibson, M.C. Preul, A. Panitch, “Influence of cross-linked hyaluronic acid hydrogels on neurite outgrowth and recovery from spinal cord injury”, Journal of Neurosurg Spine, 6(2), 133-40 (2007).
14. Y. Liu, X.Z. Shu, and G.D. Prestwich, “Reduced Post-operative Intra-abdominal Adhesions Using Carbylan™-SX, a Semi-synthetic Glycosaminoglycan Hydrogel,” Fertil. & Steril., 87(4), 940-948 (2007).
15. Y. Liu, H. Li, X.Z. Shu, S.D. Gray, G.D. Prestwich, “Crosslinked Hyaluronan Hydrogels Containing Mitomycin C Reduce Post-operative Abdominal Adhesions,” Fertil. & Steril., 83, 1275-1283 (2005).
Release of basic fibroblast growth factor froma crosslinked glycosaminoglycan hydrogel promotes wound healing
16. Y. Liu, S. Cai, X.Z. Shu, J. Shelby,G.D. Prestwich, “Fibronectin Functional Domains Coupled to Hyaluronan Stimulate Adult Human Dermal Fibroblast Responses Critical for Wound Healing”, Wound Rep Reg, 15, 245–251 (2007)
17. Y. Liu, S. Cai, X.Z. Shu, J. Shelby, G.D. Prestwich, “Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing," Wound Repair Regen, 15(2), 245-51 (2007).
18. K. Ghosh, X. Ren, X.Z. Shu, G.D. Prestwich, R.A.F. Clark, “Fibronection functional domains coupled to hyaluronan stimulate adult human fibroblasts responses critical for wound healing,” Tissue Engineering, 12(3), 601-613, (2006).
19. Y. Liu, X. Z. Shu, and G.D. Prestwich, “Tumor Engineering: Orthotopic Cancer Models in Mice Using Cell-Loaded, Injectable, Crosslinked Hyaluronan-Derived Hydrogels” Tissue Engineering, 13(5), 1091-1101 (2007).
20. X.Z. Shu, S. Ahmad, Y. Liu, and G.D. Prestwich, “Synthesis and Evaluation of Injectable, In Situ Crosslinkable Synthetic Extracellular Matrices (sECMs) for Tissue Engineering,” J. Biomed. Mater. Res. A, 79A(4), 901-912 (2006).
21. X.Z. Shu, Y. Liu, F. Palumbo, Y, Luo, and G.D. Prestwich, “In situ Crosslinkable Hyaluronan Hydrogels for Tissue Engineering,” Biomaterials, 25, 1339-1348 (2004).