Extracel™ Technology Component Origin

For research use only

Hyaluronic acid (hyaluronan) source

The hyaluronic acid used to produce Glycosil™ and HyStem™ is made by a proprietary bacterial-fermentation process using bacillus subtilis as the host in an ISO 9001:2000 process (http://www.biopolymer.novozymes.com/). It is 100% free of animal-derived raw materials and organic solvents remnants. No animal-derived ingredients are used in its production and it has very low protein levels and no exotoxins. Its production follows the European Pharmacopoeia.

Gelatin source

The gelatin used to make Gelin-S™ is derived either from Type B Bloom 225 bovine skin (http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/G9391) or from Type A Gelatin, Bloom 250, derived from porcine skin (GELITA USA, Inc, Iowa City, Iowa).

Gelatin is a heterogeneous mixture of water-soluble collagens with high, average molecular weights. The proteins are extracted either by boiling lime-cured bovine skin in water (bovine) or by acid extraction (porcine).

Heparin source

The heparin used to produce Herpasil™, Heparin A, is a heparin sodium salt, derived from porcine intestinal mucosa. It is a mixture of polyanion chains with a relatively wide range of molecular weights (17,000-19,000Da)    (http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIAL/H9399).