PEGTA

Polyethylene (glycol) tetra acrylate is a unique tool for modulating the physical properties of a hydrogel by providing double the photoreactive groups as PEGDA1.

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GS776 PEGTA 10K, 1 gram $275.00
 GS775 PEGTA 10K, 0.5 gram $165.00
 GS778 PEGTA 20K, 1 gram $275.00
 GS777 PEGTA 20K, 0.5 gram $165.00
 To order, please fax your Purchase Order to 801-588-0497 or order by phone at 801-583-8212.

Structure of PEGTA

General

Polyethylene (glycol) tetra acrylate is a unique tool for modulating the physical properties of a hydrogel by providing double the photoreactive groups as PEGDA1. 

Basic Information

Polyethylene (glycol) tetra acrylate (PEGTA, 4-arm poly(ethylene glycol) (PEG) acryl) is a synthetic, hydrophilic starting material which forms hydrogels in the presence of photoinitiator and UV light.  Like PEGDA, PEGTA hydrogels are easily customizable since ECM proteins and/or growth factors can be incorporated into a hydrogel and its stiffness can be modulated from 10-100 kPa10,11.   Since PEG is its base material, PEGTA is widely recognized as a biocompatible, non-immunogenic, and capable of chemical manipulation to incorporate attachment peptides2,7, degradable peptides2,3, and other moieties4.

Application

  • Regular and 3-D cell culture3,4,5,7
  • Tissue engineering8
  • Photolithography6,8,9

Composition

PEGTA comes in bulk (non-filter sterilized):

  • 0.5 gram of total PEGTA (for small-volume applications)
  • 1 gram of total PEGTA (for medium-volume applications)

Data Sheets

MSDS

PEGTA

References

  1. Wieland JA, Houchin-Ray TL, Shea LD, Non-viral vector delivery from PEG-hyaluronic acid hydrogels. J. Control Release (2007) 120: 233-241.
  2. Salinas CN and Anseth KS, The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities. Biomaterials. (2008) 29:2370-7.
  3. Kloxin AM, et al.Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties Science (2009) 324, 59.
  4. DeForest CA, Polizzotti BD, and Anseth KS, Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments Nat. Mater. (2009) 8: pp. 659-664.
  5. Baird IS, Yau AY, and Mann BK, Mammalian cell-seeded hydrogel microarrays printed via dip-pin technology BioTech. (2008) 44:249-256.
  6. Baek TJ et al, Photolithographic Fabrication of Poly(Ethylene Glycol) Microstructures for Hydrogel-based Microreactors and Spatially Addressed Microarrays J. Microbiol. Biotechnol. (2007) 17: 1826-1832.
  7. Taite LJ, Rowland ML, Ruffino KA, Smith BR, Lawrence MB, West JL. Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies. Ann Biomed Eng. (2006) 34:1705-11.
  8. Du Y, Lo E, Ali S, Khademhosseini A. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs Proc Natl Acad Sci U S A. (2008) 105:9522-7. .
  9. Khademhosseini A, Yeh J, Jon S, Eng G, Suh KY, Burdick JA, Langer R. Molded polyethylene glycol microstructures for capturing cells within microfluidic channels. Lab Chip. (2004) 4:425-30.
  10. Liao H, Munoz-Pinto D, Qu X, Hou Y, Grunlan MA, Hahn MS. Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production and phenotype. Acta Biomater. (2008) 4:1161-71.
  11. Patel PN, Smith CK, Patrick CW Jr. Rheological and recovery properties of poly(ethylene glycol) diacrylate hydrogels and human adipose tissue.J Biomed Mater Res A. (2005) 73:313-9.